Ugeskr Laeger. 2014 Feb 24;176(9A).
Pharmaceutical treatment of lactation deficiency lacks evidence.
Axelsson PB1, Bjerrum F, Løkkegaard EC.
In this review we have looked at the evidence for the pharmacological treatment of lactation deficiency. Five RCTs (n = 166) of metoclopramide found no effect on lactation and two RCTs (n = 26) of older date and lesser quality found significant effect. One RCT (n = 51) of syntocinon found no effect onlactation and two older RCTs (n = 60) of lesser quality found significant effect. Three RCTs (n = 105) found significant effect of domperidone on lactation. Education on breastfeeding is important to avoid the need for pharmacological treatment.